He auditioned for the cop and got cast as the angel. Charmed needed a love interest for Piper, and Krause turned a supporting role into 154 episodes across eight seasons. Before that, Return to the Blue Lagoon (1991) put him opposite Milla Jovovich, and Sleepwalkers (1992) gave him the lead in a Stephen King horror. Neither made him a household name, but they kept him working long enough to land in Charmed's audition room. He stayed until the show ended and wrote a Season 5 episode while he was at it.
Post-Charmed, the credits kept coming but the budgets got smaller. Lifetime thrillers, Sci-Fi Channel creature features, titles like Slay Ride: The Movie and Die Hart. The convention circuit fills the gaps, and he co-hosts The House of Halliwell, a Charmed rewatch podcast with Holly Marie Combs and Drew Fuller. It's not a comeback arc. It's a working actor doing exactly what a working actor does after one defining show ends.
Before the acting career took hold, he was driving a pie truck and hanging drywall. He'd wanted to study medicine at one point, which has a certain irony: Leo Wyatt was a World War II medic-turned-guardian-angel, essentially a doctor who never stopped practicing. Nobody casts for that kind of coherence. He wrote one Charmed episode, Season 5's Sense and Sense Ability, though the credit was a one-off rather than a pivot.