Nick and Norah's Infinite Playlist put her on the industry's radar in 2008, but the real making happened in 2011 when she landed two roles in the same year: Darcy Lewis in Thor and Max Black in 2 Broke Girls. The sitcom ran six seasons on CBS and turned her into a face people recognized in grocery stores. She played sardonic so well that it stopped feeling like acting.
2 Broke Girls getting canceled without a finale could have been a slow fade. Instead she reprised Darcy Lewis in WandaVision, then signed onto Shifting Gears on ABC opposite Tim Allen as both star and producer. Season 1 pulled nearly 17 million multi-platform viewers in its first week. Season 2 outrated Abbott Elementary in total viewers. Critics weren't sold (47% on Rotten Tomatoes), but those numbers make reviews beside the point.
Her real last name is Litwack. She took "Dennings" from a family friend, partly so she could tell who actually knew her versus who just knew the character. She grew up homeschooled, finished high school at 14, in a TV-free household, which makes her becoming a sitcom fixture for six years either the setup or the punchline. As a kid she introduced herself to strangers as Wednesday Addams. She married musician Andrew W.K. in 2023, which is its own kind of casting choice.