Edie Falco

Before The Sopranos, Falco had been grinding through New York theater and cable TV for years. Oz gave her a recurring role as a corrections officer; nobody was putting her name above the title. The show changed that, but not because Carmela Soprano was a compelling mob wife. It was because Falco played her as a woman who knew exactly what her husband was and stayed anyway, making that choice feel morally complicated instead of pathetic. David Chase wrote the role. Falco made Carmela the most interesting person on the show.

She won three Emmys for The Sopranos, then turned around and won a fourth for Nurse Jackie, becoming the first female performer to win the Emmy for lead actress in both drama and comedy categories. That's a record that sounds like a trivia question until you realize how rarely any actress headlines two landmark series. A Nurse Jackie sequel is in development at Amazon, which means someone still has enough faith in her to build a streaming bet around her. She's not chasing franchise work or brand deals. She picks carefully and wins.

She's been in recovery from alcohol for decades, open about AA. Playing Nurse Jackie, a character defined by drug addiction and strategic lying, required either perfect casting or a lot of self-awareness. She's said she understood the compartmentalization better than most would. A solo parent to two adopted kids (one in 2004, one in 2008) during the height of her television career. A breast cancer diagnosis in 2003, kept private for a year while she kept working.