A Disney Store catalog at age 7 was the start. A few years later he was sharing scenes with Adam Sandler in Grown Ups, which got him noticed as a kid who could hold his own against adults twice his age. Jessie made him a Disney staple across 98 episodes as Luke Ross, a role originally written for a Korean boy named Hiro that the writers rewrote entirely around him. The Descendants franchise, where he played Carlos De Vil, gave him a bigger platform. He'd announced Descendants 3 would be his last Disney project. He was 20 when he died.
The Descendants fanbase keeps him frozen at 20 in a role he'd just said he was done with. Posthumous credits include the thriller Runt (2020) and a series regular slot on Amazon Prime's Paradise City. Adam Sandler slipped a tribute clip into Happy Gilmore 2 in 2025. His foundation pivoted into epilepsy advocacy, funding a SUDEP research award through CURE Epilepsy and launching the K(NO)W SUDEP NOW! campaign. His name now appears on the Thirst Project's Pioneering Spirit Award, renamed in his honor.
His paternal grandmother, Jo Ann Boyce, was one of the Clinton Twelve, the first Black students to integrate a high school in the American South after Brown v. Board of Education in 1956. He appeared with her in a Disney XD Black History Month piece that won a Daytime Emmy. He called himself 'bl-ewish,' a riff on his biracial identity, father African-American and mother Ashkenazi Jewish. Outside acting, he trained in breakdancing, ballet, tap, jazz, and modern, and ran with a crew called X Mob. He was also a serious photographer.
Descendants 3 premiered on August 2, 2019, less than four weeks after his death. The Cameron Boyce Foundation launched the same month, with its first initiative, Wielding Peace, going live August 16. Adam Sandler dedicated Hubie Halloween to his memory on Netflix in October 2020. His foundation later partnered with CURE Epilepsy to fund the Cameron Boyce SUDEP Research Award.